Thiamine /Vitamin B1 Impurity 54 Ammonium Salt CAS 10553-88-5 (free form)
| CAS No. | 10553-88-5 (free form) |
| Molecular Formula | C12H17N4O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Thiamine /Vitamin B1 Impurity 54 Ammonium Salt (C12H17N4O5SH4N) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 347.39 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Thiamine /Vitamin B1 Impurity 54 Ammonium Salt (CAS 10553-88-5 (free form), C12H17N4O5SH4N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Thiamine /Vitamin B1 Impurity 54 Ammonium Salt meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H17N4O5S H4N |
| Molecular Weight | 347.39 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Thiamine Standards
- Thiamine Impurity 30 (CAS 100502-51-0)
- Thiamine Nitrate EP Impurity G (CAS 1037-29-2)
- Thiamine Impurity 11 (CAS 105070-51-7)
- Thiamine /Vitamin B1 Impurity 50 (CAS 10553-88-5)
- Thiamine EP Impurity F (CAS 10593-44-9)
- Thiamine disulfide (dinitrate) (CAS 109125-52-2)
- Thiamine Impurity 54 (CAS 1124-01-2)
- Thiamine /Vitamin B1 Impurity 56 (CAS 1153-39-5)
Recommended Standards
- Efavirenz Related Compound A (CAS 209414-27-7)
- Raloxifene Impurity 20 (CAS 182133-38-6)
- Gefitinib Impurity 81 (CAS CATO-C4X-111781)
- α-Amyrin (CAS 638-95-9)
- (2Z)-3-[N'-(2,4-Dichlorophenyl)hydrazinecarbonyl]-2-phenylprop-2-enoic acid (CAS 339016-58-9)
- 1-(3-Chloro-5-(trifluoromethyl)phenyl)hydrazine (CAS 96406-91-6)
- trans-1,3,3a,4,6,6a-hexahydrocyclopenta[c]thiophen-5-one (CAS 2489613-05-8)
- 3-((((1-Isobutyl-1H-pyrazol-3-yl)methyl)amino)methyl)phenol hydrochloride (CAS 1856055-47-4)
- 2-(4-Chloro-5-methyl-1h-pyrazol-1-yl)ethan-1-amine hydrochloride (CAS 1197234-40-4)
- Proinsulin C-Peptide (55-89) (human) (CAS 11097-48-6)
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